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Clinical Evidence

For more information about any publication listed below, please visit the U.S. National Institute of Health's PubMed website and search for the name of the article:

Official Published Scar Treatment Guidelines

1. Monstrey, S., Middelkoop, E., Jan Jeroen Vranckx, J.J., Bassetto, F., Ziegler, U.E., Meaume, S., Téot, L. (2014). "Updated Scar Management Practical Guidelines: Non-invasive and invasive measures". Journal of Plastic, Reconstructive & Aesthetic Surgery (2014) xx,1-9

2. Mustoe, T., Cooter, R., Gold, M., Hobbs, F., Ramelet, A., Shakespeare, P., Stella, M., Teot, L., Wood, F., Ziegler, U. for the International Advisory Panel on Scar Management. (2002). "International Clinical Recommendations on Scar Management". Plastic and Reconstructive Surgery, August 2002, 110(2): 560-571

3. Kim, S., Choi, T.H., Liu, W., Ogawa, R., Suh, J.S., Mustoe, T.A. (2013) "Update on Scar Management: Guidelines for Treating Asian Patients". Plastic and Reconstructive Surgery, 132(6): 1580-1589


Review Papers and Studies Indicating Silicone Therapy is Preferred Over Vitamin E or Onion extract (Mederma)

1. Karagoz H, et al.  "Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects". Arch Clin Exp Surg (2012)X:X

2. Arno AI, et al. "Up-to-date approach to manage keloids and hypertrophic scars: A useful guide". Burns. 2014 Nov; 40(7): 1255–1266.

3. Sidgwick GP, McGeorge, D, Bayat A. "A comprehensive evidence-based review on the role of topicals and dressings in the management of skin scarring". Arch Dermatol Res (2015) 307:461–477.

4. Kerwin, L, El Tal, AK, Stiff, MA, Fakhouri, TM. "Scar prevention and remodeling: a review of the medical, surgical, topical and light treatment approaches". International Journal of Dermatology 2014, 53, 922–936.

5. Bettini RF, Dias Souza, C, Adriano Farina Júnior, J. "Update on hypertrophic scar treatment". Clinics (Sao Paulo). 2014 Aug; 69(8): 565–573.

6. Foo, CW, Tristani-Firouzi, P., "Topical Modalities for Treatment and Prevention of Postsurgical Hypertrophic Scars". Facial Plast Surg Clin N Am 19 (2011) 551–557. 


Clinical Trials, Papers and Studies Involving the Effectiveness of Silicone Gel in Managing Scars

1. Mustoe, T. (2007). "Evolution of Silicone Therapy and Mechanism of Action in Scar Management". Aesthetic Plastic Surgery, 2008, 32:82-92

2. Atiyeh, B. (2007)."Nonsurgical Management of Hypertrophic Scars: Evidence-Based Therapies, Standard Practices, and Emerging Methods". Aesthetic Plastic Surgery, 2007, 31:468-492

3. Borgognoni, L.( 2002). "Biological Effects of Silicone Gel Sheeting". Wound Repair and Regeneration, March-April, 2002, 10(2): 118-121

4. Gold, M., Foster, T., Adair, M., Burlinson, K., Lewis, T., (2001). "Prevention of Hypertrophic Scars and Keloids by the Prophylactic Use of Topical Silicone Gel Sheets Following a Surgical Procedure in an Office Setting". Dermatologic Surgery, 27:641-644

5. Chernoff, W., Cramer, H., Su-Huang, S.( 2007). "The Efficacy of Topical Silicone Gel Elastomers in the treatment of Hypotrophic Scars, Keloid Scars and Postlaser Exfoliation Erythema". Aesthetic Plastic Surgery, 2007, 31(3):495-500

6. Li-Tsang, C., Lau, J., Chan, Y., Ho, M.( 2006)."A Prospective Randomized Clinical Trial to Investigate the Effect of Silicone Gel Sheeting on Posttraumatic Hypertrophic Scarring among the Chinese Population". Burns, 32:678-683

7. Majan, J.( 2006). "Evaluation of a self-adherent soft silicone dressing for the treatment of hypertrophic postoperative scars". Journal of Wound Care, 15:193-196

8. Chan, K., Lau, C., Adeeb, S., Somasundaram, S., Nasir-Zahari, M. (2004). "A Randomized, Placebo-controlled, Double-blind, Prospective Clinical Trial of Silicone Gel in Prevention of Hypertrophic Scar Development in Median Sternotomy Wound". Plastic Reconstructive Surgery, 116:1013-1020

9. de Oliveira, G., Nunes, T., Magna, L., Cintra, M., Kitten, G., Zarpellon, S., Raposo Do Amaral, C. (2001). "Silicone Versus Nonsilicone Gel Dressings: A Controlled Trial". Dermatologic Surgery, 27:721-726

10. Borgognoni, L., Martini, L., Chiarugi, C., Gelli, R., Reali, U. (2000). "Hypertrophic Scars and Keloids: Immunophenotypic Features and Silicone Sheets to Prevent Recurrences". Annals of Burns and Fire Disasters, 8:164-169

11. Cruz-Jorchin, N. (1996). "Effectiveness of Silicone Sheets in the Prevention of Hypertrophic Breast Scars". Annals of Plastic Surgery, 37:345-348

12. Sproat, J., Dalcin, A., Weitauer, N., Roberts, R. (1992). "Hypertrophic Sternal Scars: Silicone Gel Sheets Versus Kenalog Injection Treatment". Plastic Reconstructive Surgery, 90:988-992

13. Ahn, S., Monafo, W., Mustoe, T. (1991). "Topical Silicone Gel for the Prevention and Treatment of Hypertrophic Scars". Archives of Surgery, 126:499-504

14. Ahn, S., Monafo, W., Mustoe, T. (1989). "Topical Silicone Gel: A New Treatment for Hypertrophic Scars". Surgery 106:787-787

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